Michael Scofield (Wentworh Miller)He is a younger brother of Lincoln Burrows, who has been set up for the murder of the Vice President's brother by the group of people called "The Company.", so Michael decides to break his brother out of the prison, Fox River State Penitentiary. As you can see on his body, it is the blueprint of Fox River, which he manages to tatto it on himself before robbing the bank to get to the Fox River, and some details of his plan.
Lincoln Burrows (Dominic Purcell)Lincoln Burrows is an older brother of Michael Scofied. He has been sentenced to death for a crime he did not commit, the murder of the Vice President's brother, Terence Steadman.
Fernando Sucre (Amaury Nolasco)Fernando Sucre is Michael Scofield's inmate at Fox River State Penitentiary. He becomes Michael and Lincoln's friend, and he also involves with the breaking out plan.
Theodore "T-Bag" Bagwell (Robert Knepper)T-Bag is wicked, cruel and cunning. He will do everything he can to achieve what he wants. T-Bag is one of the most important characters in Prison Break because he has so many parts in the show.
John Abruzzi (Peter Stormare)John Abruzzi is a leader of Chicago mafia. For that reson, he becoms a prominent figure in Fox River State Penitentiary. He has a deal with Michael which is providing a plane for Michael in exchange for the location of his eyewitness.
Benjamin Miles "C-Note" Franklin (Rockmond Dunbar)C-Note accidentally knows the escape plan, so he threatens Michael that he will expose the plan if Michael does not let him join the team.
Veronica Donovan (Robin Tunney)Veronica is a lawyer and childhood friend of Lincoln and Michael. Micheal asks her to review Lincoln's case. Also, she is Lincoln's ex-girlfriend, and she does not believe for what people think Lincoln did.
Brad Bellick (Wade Williams)Bellick is the captain of Fox River officers. He is very cruel and corrupted. He receives money from prisoners in exchange for their protections. He is also one of the obstacles of the escape plan.
Dr.Sara Tancredi (Sarah Wayne Callies)Sara is a doctor who works in Fox River State Penitentiary and also a daughter of Governor of Illinois. She falls in love with Michael and later, becomes involved with the escape plan.
Lincoln "L.J." Burrows Jr. (Marshall Allman)LJ is Lincoln's son. He is in danger because of his father. The Company kills his mother and stepfather and blame him for the murder. Also, he has been chased after by the company.
Paul Kellerman (Paul Adelstein)Kellerman is a Secret Service agent who works for the Vice President to make sure that the execution of Lincoln goes smoothly.
Alexander Mahone (William Fichtner)Alexander Mahone is an FBI agent. He has been assigned to locate the fugitives. He always takes one step behind Michael.
Gretchen Louise Morgan (Jodi Lyn O'Keefe)Gretchen Morgan is one of the Company agents. She works directly to General Krantz. She first appears to be the one who makes sure about the escape of James Whistlers in Sona.
Don Self (Michael Rapaport)Don Self is a Homeland Security agent who appears in the last season. He teams up with the fugitives to take down the Company.
James Whistler (Chris Vance)Whistler first appears in season 3. He has been imprisoned in Sona by murdering the Mayor of Panama City's son.
General Jonathan Krantz (Leon Russom)Janathan Krantz is the leader of the Company. He is the one who controls everything from the beginning of the story.
Christina Rose Scofield (Kathleen Quinlan)Christina is Michael's mother. She seems to be nice, but in fact she is really evil. She shoots Lincoln and almost kills Michael.
